An aromatic shrub, 1–2 m high. Branches grey-brown to dark brown with long fl owering and short leafy shoots, bark longitudinally peeling. Leaves clustered on leafy shoots, widely spaced on fl owering shoots; petiole very short; blade linear-lanceolate to linear, 17 mm long, 2 mm wide on leafy shoots, 2–6 cm long, 3–6 mm wide on fl owering shoots; grey stellate tomentose, base attenuate, margin entire, revolute, apex obtuse.
Infl orescence a crowded, interrupted or nearly continuous spike, 2–8 cm long; verticillasters numerous, with 6–10 fl owers, upper ones densely crowded; peduncle about three times longer than the spike; bracts papery, rhombic-ovate, 3–8 mm long, rust coloured when dry; bracteoles absent or up to 2.5 mm long, pedicel 1.0–1.5 mm long; calyx 4–7 mm long, densely grey stellate tomentose outside, with 13 longitudinal ribs, upper lip entire, appendage obcordate, lower lip four-toothed; corolla 10–12 mm long, blue, base subglabrous, throat and limb glandular hairy, upper lips straight, lower lips spreading. Nutlets narrowly cylindrical.
Contains 1.0–3.0% essential oil, of which the major constituents are linalyl acetate (30–55%) and linalool (20–50%). Other constituents include β-ocimene, 1,8-cineole (1,8-cineol, cineol, cineole, eucalyptol), camphor and caryophyllene oxide. The structures of linalyl acetate and linalool are resented below.
Aqueous, chloroform, hexane and methanol extracts of Flos Lavandulae, 60.0 μg/ml, inhibited the growth of Streptococcus pneumoniae in vitro.
A methanol extract of the fl owers inhibited the growth of Helicobacter pylori (the bacterium associated with peptic ulcer disease) in vitro, minimum inhibitory concentration 100.0 μg/ml.
A 50% ethanol extract of the fl owers had antioxidant activity in vitro, median effective dose 45.0 mg/ml.
Intragastric administration of 400.0 mg/kg body weight (bw) of an 80% ethanol extract of the flowers to mice signifi cantly (P < 0.05) reduced ethanol-induced gastric ulcerations by 62.9%.
Uterine stimulating activity
A hot aqueous extract of the fl owers (dose not specified) stimulated uterine contractions in isolated pregnant guinea-pig uterus.
Anticonvulsant and sedative activities
Intraperitoneal administration of 2.5 g/kg bw of linalool to rodents protected against convulsions induced by pentylenetetrazole, picrotoxin and electroshock. In mice, intraperitoneal administration of 2.5 g/kg bw of linalool interfered with glutamate function and delayed N-methyld-aspartate-induced convulsions. Linalool acts as a competitive antagonist of [3H]-lutamate binding and as a non-competitive antagonist of [3H]-dizocilpine binding in mouse cortical membranes, suggesting interference of glutamatergic transmission. The effects of linalool on [3H]-glutamate uptake and release in mouse cortical synaptosomes were investigated. Linalool reduced potassium-stimulated glutamate release. These data suggest that linalool interferes with elements of the excitatory glutamatergic transmission.
No information available.
Uses supported by clinical data
Uses described in pharmacopoeias and well established documents
Symptomatic treatment of restlessness, insomnia, and as a carminative and antispasmodic for gastrointestinal disorders of nervous origin. Externally in balneotherapy for the treatment of cardiovascular disorders.
Uses described in traditional medicine
As a diuretic and an emmenagogue, and for the treatment of burns, diarrhoea, headaches, sore throats and wounds.
Keep it in isolation in a dry, well-ventilated and sheltered place. Protected from moisture. Recommended storage temperature is 18-20 ° С and humidity of air is 30-40%. Shelf life: 3 years.